The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders
Summary
Comprehensive pharmacological review demonstrating that Cerebrolysin mimics endogenous neurotrophic factors. In dementia models, it decreased amyloid-beta deposition and tau phosphorylation, increased synaptic density, and enhanced neurogenesis. In stroke models, it reduced infarct volume and promoted functional recovery.
Key Findings
- Decreased amyloid-beta deposition and tau phosphorylation via GSK-3beta and CDK5 regulation
- Enhanced neurogenesis in the dentate gyrus and subventricular zone
- Reduced infarct volume and edema formation in stroke models with improved functional recovery
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