Completed Preclinical (in vitro) 2003
Peptide promotes overcoming of the division limit in human somatic cells
Khavinson VKh, Bondarev IE, Butyugov AA
Bulletin of Experimental Biology and Medicine
Summary
This study investigated the effects of the tetrapeptide epithalon (Ala-Glu-Asp-Gly) on human fetal fibroblast cultures approaching the Hayflick limit. Epithalon treatment induced telomerase activity in somatic cells and enabled cells to exceed the normal replicative limit, suggesting a mechanism for age-related telomere maintenance.
Key Findings
- Epithalon activated telomerase catalytic subunit (hTERT) expression in human somatic cells that normally lack telomerase activity
- Treated fibroblast cultures exceeded the Hayflick limit by an additional 10 population doublings compared to untreated controls
- Elongation of telomeres was observed in epithalon-treated cell cultures, counteracting replicative senescence
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