Completed Review 2014

    Oxytocin, motivation and the role of dopamine

    Love TM

    Pharmacology, Biochemistry and Behavior

    DOI: 10.1016/j.pbb.2013.06.011

    Summary

    Explored the interaction between oxytocin and dopaminergic reward systems in mediating social motivation and bonding. Proposed that oxytocin enhances the salience of social stimuli by modulating dopamine release in the nucleus accumbens and ventral tegmental area.

    Key Findings

    • Oxytocin modulates dopamine release in reward-related brain regions
    • Social bonding effects partially mediated through dopaminergic reward circuitry
    • Oxytocin-dopamine interaction explains why social contact is intrinsically rewarding

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    Completed 2021

    Oxytocin and the neurobiology of prosocial behavior

    Marsh N, Marsh AA, Lee MR, et al.

    The Neuroscientist

    Comprehensive review synthesizing evidence on oxytocin's role in prosocial behavior, trust, empathy, and social cognition. Examined neural circuits underlying oxytocin's effects and evaluated the translational potential for social behavior disorders including autism spectrum conditions.

    • Oxytocin modulates activity in amygdala, prefrontal cortex, and reward circuitry during social tasks
    • Effects on trust and prosocial behavior are context-dependent, not universally enhancing

    DOI: 10.1177/1073858420960111

    Completed 2015

    Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

    Peñagarikano O, Lázaro MT, Lu XH, et al.

    Science Translational Medicine

    Demonstrated that both acute oxytocin administration and stimulation of endogenous oxytocin release restored social behavior deficits in the Cntnap2 autism mouse model. Identified reduced oxytocin-producing neurons as a key deficit and showed that treatment normalized social interaction.

    • Oxytocin administration rescued social behavior deficits in autism mouse model
    • Cntnap2 mice had fewer oxytocin-immunoreactive neurons in the paraventricular nucleus

    DOI: 10.1126/scitranslmed.3010257