Alpine Research Labs
    Completed Preclinical (in vivo) 1999

    Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents

    Faden AI, Fox GB, Fan L, et al.

    American Journal of Physiology

    DOI: 10.1152/ajpregu.1999.277.4.R1196

    PE-22-28

    Summary

    Developed a dual-substituted TRH analog (2-ARA-53a) that preserved neuroprotective activity while eliminating undesirable autonomic, analeptic, and endocrine effects. Treatment improved both motor recovery and cognitive water maze performance after traumatic brain injury in rodents.

    Key Findings

    • TRH analog improved motor recovery in rats and cognitive performance in mice after TBI
    • Successfully dissociated neuroprotective effects from endocrine and autonomic side effects
    • Suggests potential clinical role for modified TRH analogs in neurotrauma treatment

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    Veronesi MC, Yard M, Jackson J, et al.

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    DOI: 10.1016/j.brainres.2006.10.029