Selank: a short peptide with anxiolytic-like properties

Summary

This study evaluated the anxiolytic properties of selank, a synthetic analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a stabilizing Gly-Pro extension, in multiple animal models of anxiety. Selank demonstrated significant anxiolytic activity comparable to classical benzodiazepines without the associated sedation, amnesia, or dependence liability.

Key Findings

• Selank demonstrated significant anxiolytic activity in the elevated plus maze, Vogel conflict test, and open field models at doses of 250-500 mcg/kg
• Unlike benzodiazepines, selank did not produce sedation, muscle relaxation, or impairment of motor coordination at effective anxiolytic doses
• The anxiolytic effect was associated with modulation of GABAergic neurotransmission and altered expression of GABA-A receptor subunit genes