Novel pan-ERR agonists ameliorate heart failure through enhancing cardiac fatty acid metabolism and mitochondrial function
Summary
Showed that SLU-PP-332 and its successor SLU-PP-915 significantly improved cardiac ejection fraction, reduced fibrosis, and increased survival in pressure overload-induced heart failure. The ERR-gamma-mediated cardioprotection occurs through enhanced fatty acid metabolism and mitochondrial oxidative capacity.
Key Findings
- SLU-PP-332 improved ejection fraction and increased survival in heart failure model
- Normalized fatty acid and mitochondrial metabolic profiles in failing hearts
- ERR-gamma identified as the main mediator of cardioprotective transcriptional regulation
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