Neuroprotection
Definition
Neuroprotection refers to mechanisms and strategies that preserve neuronal structure and function against injury, degeneration, or disease. Neuroprotective agents may act by reducing excitotoxicity, scavenging free radicals, inhibiting apoptosis, or promoting neurotrophic factor expression. Peptides such as Semax, Selank, Cerebrolysin, Dihexa, and PE-22-28 have demonstrated neuroprotective properties through various mechanisms in preclinical research.
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Related Compounds
Semax
An in-depth review of Semax, a synthetic ACTH(4-10) analog, examining its nootropic properties, BDNF and NGF upregulation, neuroprotective mechanisms, and applications in cognitive enhancement research.
Read monographSelank
An in-depth review of Selank, a synthetic tuftsin analog heptapeptide, covering its anxiolytic mechanisms, cognitive enhancement potential, GABA modulation, immunomodulatory properties, and key published research findings.
Read monographCerebrolysin
A detailed research review of Cerebrolysin, a porcine brain-derived neuropeptide preparation with neurotrophic and neuroprotective properties studied in stroke, Alzheimer's disease, and TBI.
Read monographDihexa
An in-depth review of Dihexa, a potent angiotensin IV analog and HGF/c-Met signaling activator, examining its role in synaptogenesis, cognitive enhancement, neuroplasticity, and dementia-related research.
Read monographRelated Studies
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-induced Huntington's Disease-Like Symptoms in Rats
Wells RG, Yamamoto BK, Wright JW, et al. · Journal of Huntington's Disease (2024)
Antidepressant-like and antistress effects of Semax in rats subjected to chronic unpredictable stress
Inozemtseva LS, Karpenko EA, Dolotov OV, et al. · European Journal of Pharmacology (2024)
Cerebrolysin reduces astrogliosis and axonal injury and enhances neurogenesis in rats after closed head injury
Zhang Y, Chopp M, Zhang ZG, et al. · Neurorehabilitation and Neural Repair (2019)
Cerebrolysin: a multi-target drug for recovery after stroke
Brainin M · Expert Review of Neurotherapeutics (2018)