Follistatin gene delivery enhances muscle growth and strength in nonhuman primates
Kota J, Handy CR, Haidet AM, et al.
Science Translational Medicine
Summary
Demonstrated that AAV-mediated follistatin gene delivery produced significant and sustained increases in muscle mass and strength in nonhuman primates. This was the first primate study to confirm follistatin's myostatin-inhibiting muscle growth effects translate beyond rodent models.
Key Findings
- Follistatin gene delivery increased muscle size and strength in cynomolgus macaques
- Effects were sustained over long-term follow-up without adverse effects
- First primate validation of follistatin's muscle-enhancing properties
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