Regulation of myostatin activity and muscle growth
Summary
Foundational study establishing that follistatin is a potent endogenous inhibitor of myostatin. Transgenic mice overexpressing follistatin exhibited dramatic increases in muscle mass exceeding those seen in myostatin knockout animals, suggesting follistatin inhibits additional negative regulators of muscle growth.
Key Findings
- Follistatin overexpression produced muscle mass increases exceeding myostatin knockout alone
- Established follistatin as a natural myostatin antagonist in vivo
- Suggested follistatin inhibits additional TGF-β family members beyond myostatin
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