In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds
Summary
Demonstrated that GHK-Cu2+ complex significantly stimulates connective tissue accumulation in rat wound chambers. Treatment increased total collagen content, DNA synthesis, and glycosaminoglycan deposition in wound tissue, providing early mechanistic evidence for GHK-Cu's wound healing properties.
Key Findings
- GHK-Cu increased collagen, DNA, and glycosaminoglycan content in wound chambers
- Stimulated connective tissue accumulation in a dose-dependent manner
- Provided foundational evidence for GHK-Cu as a wound healing agent
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