The mitochondria-derived peptide humanin is a regulator of lifespan and healthspan
Summary
Demonstrated that humanin levels decline with age and that long-lived species maintain higher humanin levels. Humanin overexpression or supplementation extended lifespan and improved healthspan markers in animal models, establishing it as a key mitochondrial longevity signal.
Key Findings
- Humanin levels decline with age across multiple species
- Long-lived animal species maintain higher circulating humanin levels
- Humanin supplementation improved metabolic health markers and extended healthspan
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