Humanin, a mitochondrial-derived peptide, prevents synapse loss in hippocampal neurons
Zárate SC, Traetta ME, Bhatt DK, et al.
Frontiers in Aging Neuroscience
Summary
Showed that humanin prevents amyloid-beta-induced synapse loss in hippocampal neurons. The peptide preserved dendritic spine density and synaptic protein expression, supporting its potential as a neuroprotective agent against Alzheimer's disease pathology.
Key Findings
- Humanin prevented amyloid-beta-induced synapse loss in hippocampal cultures
- Preserved dendritic spine density and morphology under neurotoxic conditions
- Maintained expression of key synaptic proteins including PSD-95 and synaptophysin
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