AMP-Activated Protein Kinase (AMPK)
Definition
AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that functions as a master regulator of cellular energy homeostasis. AMPK is activated when the AMP-to-ATP ratio increases, signaling low energy status, and responds by stimulating catabolic pathways such as fatty acid oxidation, glucose uptake, and autophagy while inhibiting anabolic processes like protein and lipid synthesis. The mitochondria-derived peptide MOTS-c has been shown to activate AMPK signaling, and AMPK is a key node connecting metabolic sensing to exercise mimetic effects and longevity pathways.
Related Terms
Related Compounds
Related Studies
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging
Wan W, Zhang L, Chen Y, et al. · Journal of Translational Medicine (2023)
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling Pathway in Diabetic Rats
Li S, Lu H, Lu J, et al. · Frontiers in Endocrinology (2022)
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity
Kim SJ, Miller B, Mehta HH, et al. · Physiological Reports (2019)
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG, et al. · Cell Metabolism (2015)