Formulation
PEGylation
Definition
PEGylation is the process of covalently attaching polyethylene glycol (PEG) polymer chains to peptides, proteins, or other biomolecules to improve their pharmacological properties. PEGylation increases the hydrodynamic radius of the molecule, reducing renal clearance, shielding it from proteolytic degradation, and decreasing immunogenicity, thereby significantly extending the circulating half-life. This technology has been widely applied in peptide drug development, with PEGylated analogs often achieving dosing intervals of once weekly or less compared to daily injections for unmodified peptides.