Formulation
Transdermal Delivery
Definition
Transdermal delivery is the administration of a compound through the skin for systemic or local distribution. For peptides, the stratum corneum barrier typically limits passive transdermal absorption, requiring penetration enhancement strategies such as microneedles, iontophoresis, chemical enhancers, or liposomal formulations. Cosmetic peptides like Matrixyl and SNAP-8 (Argireline) are formulated for topical application, while research-grade peptides more commonly use subcutaneous or intranasal routes.