Bioavailability
Definition
Bioavailability refers to the fraction of an administered substance that reaches systemic circulation in its active form. For peptides, bioavailability varies significantly depending on the route of administration. Oral bioavailability of most peptides is typically very low (under 2%) due to enzymatic degradation in the GI tract and poor membrane permeability. BPC-157 is notable among peptides for its demonstrated stability in gastric juice, which may contribute to higher oral bioavailability compared to other peptide compounds.
Related Terms
Related Compounds
Related Studies
Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and leads to functional recovery in rats
Perovic D, Kolenc D, Bilic V, et al. · Journal of Orthopaedic Surgery and Research (2019)
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
Sikiric P, Rucman R, Turkovic B, et al. · Current Neuropharmacology (2017)
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
Chang CH, Tsai WC, Lin MS, et al. · Molecules (2014)
Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract
Sikiric P, Seiwerth S, Rucman R, et al. · Current Pharmaceutical Design (2011)