Exercise Mimetic
Definition
An exercise mimetic is a compound that replicates some of the molecular and physiological benefits of physical exercise without the actual physical activity. Exercise mimetics typically activate pathways such as AMPK, PGC-1alpha, and estrogen-related receptors (ERRs) that are normally induced by exercise. MOTS-c and SLU-PP-332 are notable peptide/small molecule exercise mimetics — MOTS-c activates AMPK to improve metabolic fitness, while SLU-PP-332 activates ERR signaling to enhance endurance capacity.
Related Terms
Related Compounds
MOTS-c
An in-depth review of MOTS-c, a mitochondrial-derived peptide encoded by the 12S rRNA gene, examining its role in AMPK activation, exercise mimicry, glucose metabolism, pharmacokinetics, safety, and aging research.
Read monographSLU-PP-332
An in-depth review of SLU-PP-332, a synthetic pan-ERR agonist and exercise mimetic compound, covering its mechanism of action via ERRa/b/g activation, research in muscle physiology, metabolic disease, and mitochondrial function.
Read monographRelated Studies
Novel pan-ERR agonists ameliorate heart failure through enhancing cardiac fatty acid metabolism and mitochondrial function
Xu W, Billon C, Li H, et al. · Circulation (2024)
A synthetic ERR agonist alleviates metabolic syndrome
Billon C, Schoepke E, Avdagic A, et al. · Journal of Pharmacology and Experimental Therapeutics (2024)
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging
Wan W, Zhang L, Chen Y, et al. · Journal of Translational Medicine (2023)
Synthetic ERR alpha/beta/gamma agonist induces an ERR-alpha-dependent acute aerobic exercise response and enhances exercise capacity
Billon C, Sitaula S, Banerjee S, et al. · ACS Chemical Biology (2023)