Pharmacology

Receptor Selectivity

Definition

Receptor selectivity describes the preference of a ligand for binding to one receptor type or subtype over others. High selectivity means a compound activates its intended target with minimal off-target effects, improving the safety profile. Ipamorelin is notable for its high selectivity for the GHS-R1a receptor without significantly affecting ACTH, cortisol, or prolactin levels, unlike less selective growth hormone secretagogues.

Related Compounds

Ipamorelin

An in-depth review of Ipamorelin, a highly selective growth hormone secretagogue pentapeptide, covering its mechanism of action, pharmacokinetics, research applications in GH release, bone density, muscle growth, and safety profile.

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Related Studies

Ipamorelin, the first selective growth hormone secretagogue

Raun K, Hansen BS, Johansen NL, et al. · European Journal of Endocrinology (1998)

More Pharmacology Terms

Bioavailability Dose-Response Curve EC50 (Half-Maximal Effective Concentration) Exercise Mimetic First-Pass Metabolism Growth Hormone-Releasing Peptides (GHRPs) Half-Life IC50 (Half-Maximal Inhibitory Concentration)

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